Multiple studies have shown that DF is a vector-borne virus that affects world health. Recent studies show that severe DF is the top cause of pediatric and adult hospitalizations. Early diagnosis and treatment are essential to avoiding complications. Even though various studies have shown interest in microalbuminuria in severe DF, there is little data on urine protein excretion during infection. In order to determine the relationship between DF severity and proteinuria, we conducted a study. Our study found proteinuria with DHF and DSS compared to DF alone, with increased FS, LM-BP, and hospital stay ratios. Thus, we conclude that proteinuria in DF patients must be detected as soon as possible in order to determine its severity and avoid dengue-related renal complications.