The current study has been undertaken to assess the pre-test Knowledge score regarding non-Hodgkin lymphoma in children among ANM Students in selected nursing school, Orissa. The research design used for study was descriptive in nature. The tool for study was self-structured knowledge questionnaire which consists of 2 parts-PART- I consisted questions related to Socio-demographic data; PART-II consisted of self -structured knowledge questionnaire to assess the pre-test knowledge score regarding non-Hodgkin lymphoma in children among ANM Students. The data was analyzed by using descriptive & inferential statistical methods. The most significant finding was that 44.0% subjects have poor knowledge, 40.0% have average knowledge score while 16.0% ANM Students were having good knowledge score.