In-situ chemical oxidative polymerization was used to develop a new series of HCl doped and silver embedded poly (aniline-co-3-trifluoromethylaniline) nanocomposites. In order to investigate these copolymer nanocomposites, FTIR, UV-visible spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and a conventional four probe conductivity approach were all used. The developed copolymer has excellent solubility in widely used organic solvents like DMF, THF, and NMP.The spectral value at 341 nm is related to π-π* electronic transition of benzenoid ring and peak at 624 nm is attributed to n-π* electronic transition of quinoidring.The band at 1300 cm-1 has been accredited to the combination of C-N in quinoid and benzenoid sequences. X-ray diffraction (XRD) reveals the crystalline nature of copolymer. Surface morphological studies exhibit nanoneedle like appearance with average particle size of 150-300 nm. Because of its less good biocompability and less toxicity recent the most recent advances on PANI applications in biomedical fields, such as antioxidant, antimicrobial and antivirus activity, drug delivery, cancer therapy, etc