Cardiac resynchronization therapy device (CRT) is a special device for heart failure patients are at high risk for sudden cardiac death. While functioning like a normal pacemaker to treat slow heart rhythms. Aim: This study evaluates the health education program for patients with cardiac resynchronization therapy devices. Research design: A quasi-experimental research design was used to utilize this study. Sample: Purposive sample includes 190 patients with cardiac resynchronization therapy devices. Setting: Outpatient clinics at the National Heart Institute. Tool for data collection: one tool used is composed of four parts, 1st part: interviewing questionnaire including socio-demographic characteristics,2nd part: Past and current complaints of patients with heart failure, 3rd part: patients’ knowledge about heart failure disease and cardiac resynchronization therapy devices, 4th part: patient's reported practice regarding cardiac resynchronization therapy device & device precautions. Results: Presents that, 66.80 % of the patients had total satisfactory reported practices while, 88.9% of the patients had an adequate level of total knowledge about heart failure disease and cardiac resynchronization therapy device post implementation of a health education program. Conclusion: The study concludes that there was a marked improvement on patient 's total knowledge & total reported practice regarding heart failure disease and cardiac resynchronization therapy devices after implementation of a health education program Recommendations: Continuous health education program for patients with cardiac resynchronization treatment devices in other places.