Inflammation, the protective strategy of our body is compared to the sprinkler system preventing a fire spread in a building. Although the work is executed with positive intentions of limiting the damage but at times can be significantly harmful. The decreased semen quality due to an inflammatory process might be a result of the impairment of an accessory gland’s function; sperm transport obstruction and spermatogenetic dysregulation. In male gonads, proinflammatory cytokines are produced physiologically in male gonads and is required in the proper functioning of the reproductive organ. Reactive Oxygen Species (ROS) disarrange probity of sperm DNA and assist to lipid peroxidation. Natural antioxidants which have free radical scavenging activity are potential remedies to treat hormonal imbalance and oxidative stress. Antioxidant can scavenge ROS, disable them and restore damage