The ongoing pandemic has unfavorably impacted oxygen creation and production network, where oxygen treatment is fundamental for the crisis treatment convention of patients contaminated by the infection. This work discusses the difficulties associated with oxygen production, storage, and transportation as well as the various oxygen generation methods. Besides, this study offers a relative investigation of different oxygen creation strategies utilizing Multi-Rules Dynamic Techniques (MCDM). Multiplicative Exponential Weighting (MEW) and Simple Additive Weighting (SAW) are selected as the statistical analysis and ranking tools for Technique for Order Preference by Similarity to Ideal Solution (TOPSIS), in addition to the weighting methods. Cost, performance, the impact on the environment, and safety are the ranking criteria. Besides, this paper uses the Entropy Weight Strategy (EWM), Standards Significance through between rules Relationship (Pundit) technique, and the Stochastic Predominance (SD) technique to appropriate the measures loads. Based on all of the tools and criteria provided, the results demonstrate that the most effective method for oxygen production is membrane technology. As it reached the TOPSIS method's maximum Entropy and Sd value of 0.548 and the SAW and MEW methods' highest CRITIC values of 0.260 and 0.236, respectively.