Marriage with in blood related persons is called as consanguineous marriage. This type of marriage can cause more effects on fetus and also on pregnancy. Health teaching regarding consanguineous marriage and its complications are needed to create awareness among people at village areas in south side of Tamil Nadu. Objectives: To Assess the knowledge regarding effects of consanguineous marriage on pregnancy outcome among women and men, to determine the effectiveness of structured teaching program regarding effects of consanguineous marriage on pregnancy outcome among women and men, to determine the association between knowledge of women and men with selected demographic variables. Research Methodology: Quantitative and evaluative approach was used in this study. One group pre-test-post-test research design, which belongs to pre-experimental design was used to collect data from 20 people with the age group of 15-60 years to conduct pilot study. First day study was explained to the subjects and an informed consent will be taken before starting the study. Pre-test was conducted by administering a structured knowledge questionnaire. On the same day, the STP was administered for 45 minutes by using visual aids and lecture cum discussion method. The post-test was conducted after 7th day. Result: The mean post test knowledge scores of women and men attending structured teaching program are highly significant than that of their pre-test knowledge scores. (P=0.01) DF= 18. Rural men and women are benefitted 29.25% after STP. Urban men and women are benefitted 32.50% after STP.