Background: The product of cardiac output (CO) and total peripheral resistance (TPR) equals blood pressure (BP). The chronic rise of arterial blood pressure is known as hypertension. An antihypertensive medicine is any medication that is prescribed to lower or normalise high blood pressure. Objective: To assess the utilization pattern of anti-hypertensive agents in the General Medicine department of ESI hospital, Ayanavaram, Chennai. Methodology: The study was a simple prospective observational study that was conducted over a six-month period. Results: 245 hypertensive cases were gathered during the research period. There were 132 (53.8%) men and 113 (46.1% females) who received anti-hypertensive therapy. Only five major kinds of antihypertensive medications were utilised in the research sample. They were diuretics, calcium channel blockers, angiotensin receptor blockers, beta adrenergic blockers, and angiotensin converting enzyme inhibitors (ACEIs). Calcium channel blockers were prescribed the most frequently 57(23.2%), whereas diuretics were prescribed the least frequently 2 (0.08%). Conclusion: In this investigation, significant variations in the use of various antihypertensive drug groups were found. These studies provide a general overview of the antihypertensive medicine prescription pattern and rational drug use. These aid in the establishment of drug policy and the encouragement of doctors to prescribe medications responsibly