Antibiotics are medicines that fight against bacterial infections in people and animals. They kill bacteria or inhibit their growth. Reserve groups of antibiotics are a class of antibiotics. This group includes antibiotics that should be treated as “last resort” options to highly specific patients and settings, where other antibiotics alternative has already failed or state to be inadequate such as multi drug resistant bacteria, which is a life-threatening infection. Twenty-two reserved antibiotics are currently present on the WHO model list of essential medicines. Hence this study will be driven to determine the statistics for rational use of reserved antibiotics.