Introduction: The clinical efficacy and results of a continuous wave of condensation technique (CWC) with a resin-based sealer and a sealer-based obturation technique (SBO) using calcium silicate sealers were compared in this randomised controlled clinical research. Methods: With the help of rotary tools and 2.5% sodium hypochlorite, root canals were created. On the basis of the obturation procedure, patients were enrolled and randomly divided into 2 groups at the following visit: CWC with AH Plus sealer and SBO with Endoseal TCS. A numerical rating scale was used to evaluate the severity of discomfort following surgery in patients. The extent of root filling, root-filling voids, and sealer extrusion were used to assess the quality of the root canal obturation. After at least six months, the subjects were asked to come back. Healing of the teeth was found as a fall in Periapical Index score and resolution of symptoms. The results were statistically compared by using the c 2 test or Fisher exact test, followed bymultivariate analysis with logistic regression. Results: The evaluation covered 74 teeth (79% recalls), and the average follow-up time was 17 months (6-29 months). The spectrum of postoperative discomfort was equivalent in both of the groups (P =.973), and the quality of root canal obturation was comparable. Without no discernible differences between the 2 groups, the overall success rates were 93.2% (CWC 92.3%, SBO 94.3%) by loose criteria and 60.8% (CWC 51.3%, SBO 71.4%) by tight criteria. In comparison to teeth lacking sealer extrusion, the success rate by loose criteria was significantly lower in teeth with sealer extrusion (P 5.049). Conclusions: SBO employing an Endoseal TCS may be a viable substitute for CWC employing AH