OBJECTIVE: Vacuum-assisted closure (VAC) is an interventional, proactive injury treatment technique that exposes the wound bed to localized sub-atmospheric pressure, drains fluid from the extracellular space, enhances circulation, and promotes the growth of granulation tissue. The study goal is to determine how frequently wounds become infected, how long it takes to prepare a wound for skin-covering procedures, and how long it takes for a uniform granulation tissue bed to form in wounds that are being treated with vacuum-aided closure after main fracture fixation. METHODS: This prospective randomized controlled study included patients between the ages of 18 and 60. The fracture was treated with primary internal fixation as quickly as feasible, and then VAC was used. Cases' functional results were documented throughout each follow-up. RESULTS: After primary internal restoration with VAC, 30 patients with both leg bone open fractures were reported in this research. Following VAC treatment, the effective reduction in wound size (mean ± standard deviation) was 9.97± 9.59 cm2, with a P-value of 0.0481. With the use of this approach, wound size, infection, and functional outcomes have all been significantly reduced. CONCLUSIONS: The main benefit of VAC has been identified as accelerating the formation of gingiva on injuries with accessible tendons and bones, open implants, exposed raw regions, and wounds. This helps with recovery times and soft tissue problem repair techniques.