Piracetam belongs to the derivatives of GABA. It belongs to BCS Class I which are having high permeability and high solubility. Piracetam was first synthesized in 1964 at the Belgian pharmaceutical company UCB by Dr. Corneliu, This medication is used to treat cognitive disorders associated with ageing, dizziness. This drug was first chemical agents possess memory enhancing capacity also known as nootropics ("smart drugs" or "cognitive enhancers"), Piracetam present in combine forms with like, levetiracetam, birvaracetam. Aim of this review to study the different analytical estimations of Piracetam and comparison study with other drug molecule. It also offers a brief description of various works already done on Piracetam.