Levocetirizine is a second-generation, non-sedative antihistamine known for its potent effects and fast onset of action, which lasts longer compared to other antihistamines. A review article explores various analytical methods for determining levocetirizine dihydrochloride in amalgamation with other drugs such as Ambroxol hydrochloride, montelukast sodium, salbutamol sulphate, pseudoephedrine, phenylephrine hydrochloride, phenylpropanolamine hydrochloride, and acebrophylline. These combination drugs are commonly used for treating conditions like rhinitis, chronic obstructive pulmonary disease, seasonal allergies, and asthma. The study's findings indicate that the proposed methods, which include spectroscopic techniques and chromatographic techniques like UV-Spectroscopy, HPLC, RP-HPLC, and HPTLC, are precise, accurate, and reproducible for the, immediate approximation of levocetirizine and the above mentioned drugs in tablet dosage form.