The Niosomes is a targeted drug delivery system wherein medication is encapsulated within vesicles composed of a bilayer of non-ionic surface-active agents, hence the name "niosomes." Niosomes are microscopic and small in size, typically in the nanometric scale. They have demonstrated significant advancements in transdermal drug delivery and targeted drug delivery. Niosomes are formed primarily by incorporating cholesterol and surfactants as excipients, where cholesterol is crucial for stability and entrapment efficiency. Other charged molecules are also used to enhance stability, and niosomes can be unilamellar or multilamellar vesicles. They resemble liposomes and can encapsulate both hydrophilic and lipophilic drugs.The components for niosome preparation include cholesterol, non-ionic surfactants (such as spans, tweens, and brij), and charged molecules (like dicetyl phosphate or stearyl amine). Cholesterol's content influences stability, loading capacity, and vesicle formation. The preparation methods for niosomal gels vary, with techniques like Thin-Film Hydration, Ether Injection, Hand-Shaking, Reverse Phase Evaporation, and Microemulsion Template being common. These methods involve steps such as creating a lipid film, hydration, emulsification, and incorporation into a gel matrix.The advantages of niosomal gels include their potential for targeted and controlled drug delivery, improved stability of encapsulated drugs, enhanced penetration through the skin barrier, and the ability to encapsulate both hydrophilic and lipophilic drugs. Additionally, niosomal gels can offer a sustained release of drugs, reduce side effects, and improve patient compliance.Overall, niosomes represent a promising avenue for drug delivery, offering versatility and potential benefits in various medical applications.