This review article delves into the intricate details of two fascinating plants, Sauromatum venosum and Leonotis nepetifolia, exploring their biological activity, cultivation methods, fertilization requirements, and chemical constituents. Both plants boast diverse properties that have garnered attention in various fields, making them subjects of interest for researchers, horticulturists, and pharmacologists.Sauromatum venosum, commonly known as the Voodoo Lily, exhibits unique biological activity owing to its rich array of secondary metabolites. The plant's tubers have been traditionally utilized in folk medicine for their antimicrobial, anti-inflammatory, and antioxidant properties. Scientific investigations have unveiled the presence of alkaloids, phenolics, and flavonoids, contributing to its pharmacological significance. Cultivation of Sauromatum venosum requires specific conditions, including well-drained soil and partial shade. Fertilization practices play a crucial role in optimizing growth and enhancing the plant's medicinal potential.On the other hand, Leonotis nepetifolia, commonly known as Lion's Ear or Wild Dagga, has gained prominence for its diverse biological activities. The plant's leaves and flowers are renowned for their analgesic, anti-inflammatory, and anxiolytic effects, attributed to sesquiterpenes and alkaloids present in the plant. Cultivating Leonotis nepetifolia requires a warm climate, well-drained soil, and ample sunlight. Fertilization strategies influence the production of active compounds, enhancing the plant's therapeutic potential. Understanding the chemical constituents of these plants is imperative for harnessing their medicinal benefits. Chemical analyses have identified specific compounds responsible for the observed biological activities, paving the way for potential pharmaceutical applications. Additionally, insights into cultivation and fertilization practices provide valuable guidance for horticulturists seeking to optimize yield and quality.