Pharmaceutical researchers face significant obstacles when attempting transdermal medication delivery. Avoiding the effect of first pass, the transdermal route's lack of invasiveness, and substantial compliance among patients make it the preferable administration method. Therefore, it is important to create a carrier system that efficiently transports the medicine over the skin. Despite their benefits, TDDS have a few drawbacks, one of which being their inability to be used with hydrophobic medicines. New nanostructures present numerous openings for improving TDDS to deal with their inherent difficulties. Due to their high loading capacity and simple modification and functionality, polymeric nanofibres provide a novel framework for applications involving the delivery of drugs. Transdermal batch loaded with anti-hypertensive medicaments found its importance in cardiovascular diseases as hypertension is one of the most common diseases afflicting humans. Although not a medical condition in and of itself, high blood pressure is a major contributor to cardiovascular-related deaths and illnesses. In the present article, we take a quick look at what's been done so far to make and administer antihypertensive nanofibres as transdermal patches, which has been shown to significantly boost their bioavailability.The purpose of this study is to provide a comprehensive overview of the current status of research into polymeric nanofibres, focusing on: TDDS based on nanofibres.