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ISSN 2063-5346
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A REVIEW ON NANOGEL: RECENT APPROACHES AS TARGETED DRUG DELIVERY

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Km Priyanka1*, Dev Prakash Dahiya2
ยป doi: 10.48047/ecb/2023.12.si5a.0598

Abstract

Nanogel is developed by dispersing hydrogel by physical and chemical cross-linking polymer at the nanoscale size. Nanogel has a unique combination of solid and liquid characteristics. It is hypothesized that the longer the nanoparticles remain in contact with the skin after being entrapped in a nanogel, the more effective the treatment will be. The present review was based on the techniques of preparation, evaluation, applications, advantages, and limitations of nanogel formulations as described in the articles from various reputed platforms i.e., Scopus, PubMed, Medline, Google Scholar etc. Nanogels are prepared by using various techniques i.e., Emulsion Solvent Diffusion, Nano-precipitated, Emulsion Solvent evaporation, Reverse micellar and Modified emulsification โ€“ diffusion. Nanogels are evaluated and characterized in terms of their physical appearances, pH, spread ability, particle size distribution, homogeneity. drug content, FTIR, SEM, viscosity, in-vitro drug release and stability. They do not show creaming, flocculation, coalescence & sedimentation that are inherent in the process. Based on behaviour of nanogels towards stimuli, nanogels are classified in major 5 types as described. As the smaller the particle size, the greater the surface area, and thus the greater the activity, nanogels have been useful in delivering the better action or potency of the medicine. In conclusion, nanogels are more efficient drug delivery pathway with targeted drug delivery. It is highly promising in new era of pharmaceutical drug design and development as it lowers the adverse effects/ toxicity by minimising its reach to adjacent organs.

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