Proniosomes, prepared in dry form and hydrated by agitation in hot water to form niosomes provide an alternative with prospective for drug delivery via the transdermal route. The transdermal route of drug delivery has many advantages for administration of drugs in local and systemic therapy. But skin is widely recognized for its effective barrier properties compared with other biological membranes. The low permeability of the skin makes it a dermal delivery is an alternative route, but dermal delivery is an alternative route. Newer drugs of lipophilic nature emerge poor bioavailability, irregular absorption, and pharmacokinetic changes. Therefore, this novel drug delivery system has been proved advantageous over other oral and topical delivery of drug candidates to bypass such disruption. This Proniosomal gel basically is a compact semi-solid liquid crystalline (gel) composed of non-ionic surfactants easily formed on dissolving the surfactant in a minimal amount of acceptable solvent and the least amount of aqueous phase and phosphate buffer. Topical application of gel under occlusive condition during which they are converted into nisomes due to hydration by water in the skin present itself. Proniosomal gels are typically present in transparent, translucent, or white semisolid gel texture, which makes them physically stable throughout storage and transport. This review provides an important overview of the preparation, formulation, evaluation, and application of Proniosomal gel as a drug delivery carrier.