Drynaria quercifolia (DQ) also known as oak leaf plant, is epiphytic therapeutic greenery. The DQ rhizome and leaves are significantly used to promote health. The plant is a member of the polypodiaceae family and is widely used by traditional communities around the world to treat a variety of ailments based on their traditional uses. Phytoconstituents isolated from the plant include friedelin, epifriedelinol, β-sitosterol, β-amyrin, 3,4-dihydroxybenzoic acid, β-sitosterol 3-β-D-glucopyranoside, naringin, naringenin and acetyl lupeol. The plant is used as an analgesic, anti-inflammatory, anti-arthritic, anti-fertility, antimicrobial, anthelmintic, antipyretic, antidiabetic, antihyperlipidemic, thrombolytic, antiurolithiatic, antiulcer, antifungal, antihelmintic, cytotoxic and mosquito repellent. Compounds isolated from the plant that are responsible for the pharmacological activities. So far, the review has provided phytochemical and pharmacological action of the plant.