Benzothiazole (1, 3-benzothiazole) is one of the heterocyclic compounds, which is a weak base having varied biological activities. The unique methine center present in the thiazole ring makes benzothiazole as the most important heterocyclic compound. Various compounds such as hormones, alkaloids antibiotic, essential amino acids, hemoglobin, vitamins, dyestuffs and pigments have heterocyclic structure. In this review an extensive literature survey over the last decenary describes the role of benzothiazole (heterocyclic compounds) derivatives in the sector of medicine and pharmaceutical. The Delta and Omicron variants have also made the situation more challenging. To overcome this critical situation thiazole/thiadiazol /benzothiazole based thiazolidin-4-one is the most active compound with the higher inhibitory capacity to SARS-CoV-2 protease have been reported Such compounds are effective against various types of cancer cell lines through a legion of mechanisms.