An extremely high prevalence of skin malignancies and other related abnormalities are caused by the rare genetic illness known as Xeroderma pigmentosum (XP), which is characterized by extraordinary sensitivity to ultraviolet (UV) light. There are various complementation groups that XP can be categorized into, with group C being the most common in India. The goal of this paper is to give a brief outline of the history of group C cell Xeroderma pigmentosum in India.