Natural polymer is environment friendly in nature, and it is mainly taken from the plants and sometimes from animals if needed. Some common examples of it are protein, common rubber and starch. Various types of physio-mechanical variables like absorption of moisture, variation in weight, content regarding drugs. An in vitro drug executed by semi permeable membrane whereas, ex vivo drug executed by buccal mucosa. The component of pharmaceutical formulation is: Active ingredient and recipient is assembling of the dosage and the guidelines regarding it. It plays a major role in the formation of dosages; the magnitude towards the drugs should be harmious, harmless, immovable and fruitful. The broader division of polymers consists of semi synthetic, synthetic and natural polymer, it is used as the envious agents, defensive agents in the delivery system of the oral drug. Nowadays, it has been observed that the use of natural polymer is increasing day by day instead as the side effects caused by the semi synthetic and synthetic polymer is concerned.