Telmisartan is poorly water-soluble drugs belong to Biopharmaceutics Classification System (BCS) class II drug having very low solubility as well as low oral bioavailability. In this study, nanosuspension of Telmisartan was formulated using the antisolvent precipitation-ultrasonication method having different Solvent: Antisolvent Volume Ratio 1:8. Poloxamer 407 was used as Stabilizer in Telmisartan nanosuspension respectively. Plackett-Burman design was utilized to determine which factor has the biggest impact on the quality, stability, and effectiveness of the nanosuspension. Mean particle size and saturation solubility, was assessed using 32 complete factorial design and other metrics including cumulative percentage released (CPR) at two minutes, zeta potential, polydispersity index (PDI), and percent weighted drug content was also assessed. Formulations of Telmisartan nanosuspension batch TFD6 showed Mean Particle Size (nm) (Mean ± SD) (325.7 ± 6.6) and Saturation Solubility (µg/ml) (Mean ± SD (102.61 ± 1.34) respectively. Comparison was evaluated in-vitro dissolution of nanosuspension with marketed formulation and un-milled suspension.