Coronary Heart Disease is a disease of attention as it is increasing in elderly as well as involving young population. Trace elements are important in many biochemical reactions and their concentration in blood may be related to CHD. Elevated levels of serum IL-6 are a powerful predictor of cardiovascular mortality and mortality from all causes. A cross sectional analytical study was done. Total 200 cases and 200 controls were engaged in study after applying inclusion and exclusion criterion. Serum level of copper, zinc and Il-6 was recorded. Most common group was 50-59 year age group. Serum level of copper and zinc was significantly low in cases than controls. Level of Il-6 was found significantly high. In conclusion copper Deficiency and deficiency of zinc have significant relationship with CHD. Level of Il-6 very much increased in patients of CHD.