Adenocarcinoma of the prostate is one of the most common form of cancer in men, accounting for 29% of cancer in the Western World. Incidence of carcinoma prostate increases proportionally after 50 years of age. Carcinoma prostate constituted the second commonest group next to BPH (Benign Prostatic Hyperplasia) and it is the second important cause of cancer-related death in men after lung cancer. Prostatic cancer is the sixth underlying reason of mortality due to malignancies worldwide. A Cross-sectional study (both prospective and retrospective) from August 2019 to July 2022 was carried out in the Department of Pathology, MMIMSR, Mullana (Ambala). 50 prostatic resection TURP (Transurethral Resection of prostate) samples were included in this study. All relevant clinical findings were noted and histopathological examination were done. This study concluded that in patients with prostatic adenocarcinoma, there is a statistically significant correlation between increasing serum PSA levels and Gleason score. The mean PSA level was found to have statistically significant correlation with presence of perineural invasion. Based on findings of the current study, Gleason score is a prognostic factor for PNI among cases who undergo prostatic surgery. Hence, further studies involving larger multi-specialty hospitals and large group of population are recommended to validate results of present study. Such studies should also examine other prognostic parameters which can help in a disease free survival for the patients. This will further enhance prognostication and estimation of the risk of disease progression.