Background: To evaluate different irrigation systems for removal of intracanal medicaments. Materials & Methods: A total of forty freshly extracted mandibular premolars were enrolled. Each tooth was longitudinally divided into two sections, with careful removal of any debris. Subsequently, the two halves were reassembled and filled with Ca(OH)2 before being split into four distinct groups. For Group III, the teeth received irrigation with 5 mL of 2.5% NaOCl, along with the application of an ultrasonic unit. In Group IV, the teeth were irrigated using 5 mL of 2.5% NaOCl, and a CanalBrush was employed to eliminate the Ca(OH)2.