BACKGROUND: Sleep is a part of normal human physiology, affects the capacity of individual learning, academic performance and neural-behavioral functions. Sleep cycle is regulated by the circadian rhythm. Sleep consists of two phases that alternate with one another throughout the sleep cycle. Academics are major part, which affects sleep cycle, which in return affects academic results. Medical students are one subgroup of the general population who appear to be especially vulnerable to poor sleep, perhaps due to the long duration and high intensity of study that can be emotionally challenging, and lifestyle choice. OBJECTIVES: To study the sleep disturbances and sleep quality among medical students and to determine the association of sleep disturbances and sleep quality with academic performance. METHODOLOGY: It was an Institutional based analytical cross-sectional study done among Medical students(n=600) of all four academic years in two months. EPWORTH SLEEPINESS SCALE (ESS): self- administered questionnaire used to assess daytime sleepiness. PITTSBURGH SLEEP QUALITY INDEX (PSQI): a self -rated questionnaire which assesses sleep quality and disturbances over a 1-month time interval. The data collected had been entered in Microsoft excel and analyzed using SPSS 26 software. RESULTS: Out of 600 study subjects based on PSQI, 206(34.3%) of them have mild sleep difficulty, 202(33.7 %) had moderate sleep difficulty. According to ESS,332(55.3%) had higher normal daytime sleepiness, 19(3.2%) had severe excessive daytime sleepiness. There was statistical significance between ESS, PQSI and academic grades. (P<0.05). CONCLUSION: Sleep quality and sleep disturbances had significant influence on academic performance of the medical students.