Background: Multidrug resistant tuberculosis is caused by bacteria that are resistant to at the minimum two anti-tuberculosis medications: rifampicin and isoniazid. It can occur of a patient's treatment or as a result of a primary infection with resistant bacteria. It is a sprain of mycobacterium tuberculosis severely treated control of tuberculosis and effort of its prevention. It is the most important public health problem, with higher mortality rates than drug-sensitive tuberculosis, particularly in patients with compromised immune systems. Method: The investigator had prepared awareness programme regarding multi drug resistant-tuberculosis and awareness was delivered by lecture cum discussion method by using lesson plan and AV aids. The study was conducted in selected DOTS centers at Moradabad. The samples were consisted of 60 tuberculosis patients and data was collected by using non-probability purposive sampling technique and the design used pre-experimental research (one group pre-post test design). Pre test was given with the help of self structured knowledge questionnaire and 5 point likert Scale. Subsequently, awareness program was delivered by using lesson plan and AV Aids, and post test was done after 7 days.