Warts are the most viral infection that are encountered in the dermatological practice which are caused by Humanpapilloma virus. Warts are benign epidermal proliferations that have been recognized for thousands of years.The aim of the study was to assess the effectiveness of an information pamphlet on knowledge regarding warts among high school children.This was a quantitative type of study which was done among high school children. A quasi – experimental pre-test and post-test one group research design was adopted to assess the effectiveness of information pamphlet on knowledge regarding warts among the high school children. Methods and Material : Based on non – probability purposive sampling method 150 samples were selected. The study was carried out at English and Marathi – medium schools of Pune city and the samples were high school children. The tool consisted of a structured questionnaire for data collection based on the demographic variables and questions related to warts. Analysis was done by using the descriptive and inferential statistics. Frequency and percentage was found out to describe the pre-test and post-test knowledge score. Paired ‘t’ test and chi – square test were applied for data analysis. Result:- The major finding of the study shown that, there was an effect of information pamphlet on the high school children regarding information related to warts. The mean score in pre-test was 8.51 and in post-test was 15.1, which shows the effectiveness of information pamphlet on knowledge regarding warts among the high school children. Conclusion:- The pre-test and post-test mean scores were 8.51 and 15.1 respectively. This indicates that, there is a significant difference in knowledge level before and after administration of the information pamphlet on warts. Hence, the research finding had shown that administration of the information pamphlet regarding warts was effective on the knowledge level of high school children.