Background: MIS-C is a new and rare disease, simulation can be used an effective method to introduce the disease while providing a safe environment for nursing students to learn the management of MIS-C. Aim: The aim of the study was to evaluate the effectiveness of Simulation Based Learning Regarding Management of MIS-C. Methods and Materials: A Quasi Experimental Non-Equivalent Control Group Pre-Test Post Test research design was used in this study. The data was collected by using Structured Knowledge Questionnaire, Objective Structured Clinical Evaluation and Structured Clinical decision making ability Questionnaire. Results: The result shows that mean post-test knowledge scores (16.24+4.91) were higher than the mean pre-test knowledge scores in experimental group. The mean post-test skill score (23.10+4.08) was higher than the mean pre-test skill scores in experimental group and the mean post-test clinical decision making ability score (6.93+2.08) was higher than the mean pre-test clinical decision making ability score in experimental group. There was a low positive correlation between post test knowledge and clinical decision making ability score and low correlation between post test knowledge and post test skill score in Experimental group. Conclusion: Simulation based learning was effective to improve the competency in terms of knowledge, skills, clinical decision making ability of MIS-C among nursing students.