The aim of study sought to increase the knowledge and practice regarding body mechanics among staff nurses working in Ganga Sheel Advance Medical Institute, Bareilly, U.P. The objective of study was To assess the knowledge and practice regarding body mechanics among staff nurses, To evaluate the effectiveness of educational programme on knowledge and practices regarding body mechanics among staff nurses, To find association between the post-test level of knowledge and practice regarding body mechanics and selected demographic variables. The sample was conducted at Gangasheel advance Ganga Sheel Medical Institute, Bareilly, U.P. Sample size: 60 samples were collected by a convenient sampling technique. Method: Data was collected using self-structured knowledge questionnaires and observational practice checklist. The collected data was organized in master data sheet and analyzed using descriptive and inferential statistics as per the objectives of the study. Results- the sample characteristics in the present study showed that out of 60 staff nurses, the majority of the participants majority of Staff Nurses 21(35) % were in the age group of 22-25 years, 18 (30%) were in the age group of 26-29 years 9 (15) % were in the age group of 30-33 years, and 12 (20%) were in age group of above 33 years. In gender, 22 (37%) were male and 38 (63%) were female, the majority of educational status, 36 (60%) were GNM, 12 (20%) were B.Sc. Nursing 9 (15) % were Post B.sc nursing and 3 (5%) were in M.sc nursing. Majority of staff nurses i.e. 25 (42%) were having 1-3 year experience, 14 (23 %) were having 4-6 years and 12(20%) were having <6 years. 9 (15) % were having experience of <1 years Staff nurse 45 (75 %) have area of working in ward, 8 (13%) were having area of working in ICU, 4 (7%) were having area of working in O.T and 3(5%) were having area of working in OPD. Majority of staff nurses, 9(15%) were fresher staff nurses, 28(47%) junior staff nurses, 17 (28%) were senior staff nurses and 6(10%) were nurse in-charge. The result revealed that There is no significant association between mean pre-test knowledge score with the age, gender, education of staff nurses as P value is greater than 0.05 level of significance, while there is significant association between mean pre-test knowledge score with year of experience, area of working and position of staff nurses as calculated P value is lesser than 0.05 level of significance. The obtained mean difference was found to be statistically significant. The calculated “t” value (7.74) is which are greater than the table value at 0.05 level of significance at df 59 (1.67). The mean Post test practice score of Staff Nurses is 21, which is higher than the mean Pre -test practice (15.5), with the mean difference of 5.5. The obtained mean difference was found to be statistically significant. The calculated “t” value is 8.1 which are greater than the table value at 0.05 level of significance at df (59).