A current study which analyzed all foremost world ethnic groups in relation to cardiac disease initiated that Indians have the maximum threat of coronary heart disease, with shows three to four times higher than Americans, six times greater than the Chinese and 20 times more than the Japanese. In North India, 7-10% of community have coronary heart disease ( CAD) has gradually increased in India throughout the latter half of the century and is the major cause of mortality burden in the world. Global burden of cardiac disease study guesstimate that by the year 2020, the burden of atheroembolic cardiovascular disease in India would surpass that in any other province in the world. Regrettably, the participation of above factors has been evaluated typically in seclusion, even though their purposeful interrelations and links with behavioral factors. Additionally, there may be detailed dealings between individual symptoms of depression and certain psycho physiological mechanisms, somewhat with general depression, further complicating the notion of depression as a cardio toxic factor. The comparatively understudied density of the relation among depression and CAD may give out as enlightenment for the decision that depression management does not or hardly influence cardiac upshot. Future studies should hub on the network of psycho- physiological and (behavioral) factors to elucidate their precise role and timing in depressed cardiac patients, that's why the study will be aim to involve the patient and family for the participation in care for the better outcome.