A descriptive research study was conducted to assess the occurrence of sepsis and its risk factors and outcome among the patients admitted to the intensive care unit in a selected hospital, Kolkata, West Bengal. The objective of the study was to assess the occurrence of sepsis and its risk factors and outcome among the patients admitted to the intensive care unit. The researcher adopted a non-experimental survey research design for the study.130 patients who were admitted to the intensive care unit were selected as sample of the study using the non-probability consecutive sampling technique. Data were collected with a record analysis proforma based on SOFA (Sequential Organ Failure Assessment) criteria and some other laboratory parameters for the occurrence of sepsis, the record analysis proforma on risk factors of sepsis and on outcome of sepsis.The study result revealed that the occurrence of sepsis was 27.69% among them 61.11% were community acquired sepsis and 38.89% were hospital acquired sepsis.