The maximum regularly occurring cancers, which impacts a huge section of the population and has an excessive morbidity, is Skin Cancer. Surgical operation, radiation, and chemotherapy are the main treatment therapies presently used, all of which ultimately kill affected cells. Numerous nanoscale substances have been recognized as suitable companies for supplying a selective response to malignant cells and neoplasms that allows to get round this restriction. Because of their useful nanometric dimensions, nanotechnological approaches were greatly utilized in many fields. Skin cancer's devastating global impact is reawakening modern medical methods and target-specific remedy delivery systems for the chosen advantages of reduced harmfulness and tackling proliferative episodes of skin cancer. This review focuses on nanoparticles including liposomes, ethosomes, nanofibers, solid-lipid nanoparticles, metal nanoparticles, and nanofibers developed nano systems for anti-cancers that reveal exquisite repercussions for skin cancer along with its pathophysiology and treatment barriers. The review also focuses on skin cancer with its sub-types that are briefly defined, then a compilation of nanotechnological units is offered, at the side of healing uses of drug-loaded nano structures for pores and skin cancer.