In the current era numerous formulations have been developed in the present day that takes the form of vesicular carriers, such as liposomes and niosomes, which are Among the candidates for drug delivery Via oral administration. Bile salts and enzymes are Only occasionally used. These vesicular structures improve The formulation’s stability in the Gastrointestinal tract and solubility of lipophilic medications. The ultra-Deformable Flexibility of bilosomes improves the permeability of the stratum corneum. Therefore, these Have Used in the transdermal and oral delivery of medication. These vesicles are used to Administer drugs topically, Such as ocular and intranasally. In conclusion, the stability, low Toxicity, and bioavailability of bilosomes make Them preferable to other traditional vesicular Carriers liposomes and niosomes.