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ISSN 2063-5346
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A SYSTEMATIC OVERVIEW ON IMMEDIATE-RELEASE TABLET FORMULATIONS

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Ansari Mushahid, Patil Pratik, Chavhan Sandip, Avinash Gangurde, Vinod Bairagi
» doi: 10.53555/ecb/2022.11.12.229

Abstract

The field of pharmaceutical drug delivery is faced with significant challenges, but traditional pharmaceutical dosage forms continue to maintain their dominance. Immediate release dose forms refer to pharmaceutical formulations in which a minimum of 85% of the indicated quantity dissolves within a period of 30 minutes. Superdisintegrants are employed in order to enhance the effectiveness of solid dosage forms. The formulation of the tablet primarily involves the utilization of superdisintegrants such as croscarmellose, sodium starch glycolate, and crospovidone, among others. The superdisintegrants facilitate rapid disintegration of the tablet upon ingestion in the gastric environment. Consequently, the reduction in disintegration time leads to an improvement in the rate at which the drug dissolves. The quick disintegration observed in this context can potentially be attributed to the swift absorption of water from the surrounding medium, resulting in swelling and subsequent bursting, which in turn enhances the bioavailability. Tablet formulations are predominantly favoured due to their cost- effectiveness in terms of manufacturing, packaging, and distribution, as well as their enhanced stability. Tablets are widely recognized as a highly effective and commercially viable method of oral medication administration, offering numerous advantages over alternative dosage forms. This article presents a comprehensive analysis that highlights the importance of superdisintegrants in facilitating the quick release of tablets. It also explores the mechanism of disintegration, as well as the standard procedures and new granulation technology employed in the preparation of immediate-release tablets.

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