Palliative car is an important component in the path to changing the levels of the sickness's negative impact on patients who are seriously ill and their families. This systematic review will assess data-driven programs in palliative care in order to identify strategies that work well in terms of symptom management, psychosocial support, and the end-of-life-of-life milieu. The review attempts to specify the findings derived from a search of the literature that has been accomplished, including clinical trials, observational studies, and systematic reviews. We share critical strategies, accomplishments, and suggestions for healthcare professionals' daily activities that support exceptional palliative care to enrich the service.