A dreadful epidemic was caused by Hughli fever in 1860s which ruined the Hughli district in various ways. Around 66% people died of the district within twelve years. Helmets were depopulated overnight, countrymen migrated to different places to save their lives. The British Govt., local Zamindars tried to save the district but failed.The health system was damaged by the fever.Doctors and village kabirajs became puzzled looking the deaths. High price, poverty, scarcity of medicine, depress etc. were turn the people towards death. The social system almost brock down and all rushed to temple and kabiraj for survive. To control the epidemic the Govt. took several steps like digging new canal, destruction of forest, opening dispensary, import quinine, appointment of new doctors etc. The Hughli fever made change on socio-economic life, environmental, medical system, religious system etc. It is noteworthy that the British Govt. did neither exempted farmers from land revenue nor relief distributed in Hughli district. As a result, epidemic took demon character in 1860s to 1870s around twelve years.