Failed assisted reproductive technology (ART) is a challenging fact. Therefore, different immunomodulatory agents are being investigated. This study aimed to assess a novel therapeutic protocol consisting of progesterone (IM and suppository), low-dose aspirin, folic acid, lipid emulsion, prednisolone, and low molecular weight heparin (LMWH). Methods: One hundred patients were randomized into control and interventional groups (50 females for each). The control group underwent the standard treatment consisting of progesterone, folic acid, and low-dose aspirin. In addition to the standard treatment, the interventional arm received lipid emulsion, prednisolone, and low molecular weight heparin (LMWH). Results: The interventional group demonstrated significantly higher chemical (54.0% vs. 40%) and clinical (40.0% vs. 30%) pregnancy rates than the control group but without statistical significance (P = 0.161 and 0.295). Furthermore, the interventional group showed higher ongoing pregnancy (85%) than the control arm (60%), with a borderline significance (P = 0.094) Conclusion: Intravenous lipids could improve pregnancy outcomes in patients with high Natural Killer (NK) cells and failed ART. Further studies with larger sample sizes are recommended to confirm the value of intralipids and adopt their use in clinical practice.