There are very few literatures on Acute Pancreatitis as an initial manifestation of SLE. SLE is a multisystem autoimmune disease which can present from classical to atypical forms. This case reports a 29-year-old female with SLE whose early presentation was abdominal pain, abdominal distension with vomiting and fever, elevated pancreatic enzymes with pancreatic enlargement in USG and other deranged reports for which the use of steroids led to reduction in clinical symptoms indicating the importance of early diagnosis and management resulting in favorable outcomes.