Degenerative disc disease in the spine can cause the pain known as lumbosacral sciatica. Frequently, lumbar discomfort radiates down the leg, limiting a person's range of motion and impairing their ability to function normally. Sciatica is a common medical condition that can cause severe discomfort and even disability. Objective: The current study set out to do just that by looking at how well high intensity laser therapy complements interferential current therapy in relieving sciatica pain. Patients and methods: Forty patients, 20 males and 20 females, aged 30 to 50 who had been referred for treatment of sciatica pain, were split evenly between two groups. For a total of 12 sessions over the course of 4 weeks, 3 sessions per week, each session lasting for 60 minutes, the study group received high intensity laser therapy in addition to a selected physical therapy programme (interferential current, stretching and strengthening exercises for the lumbar and hip muscles), while the control group received only a selected physical therapy programme. The Straight Leg Raising (SLR) Test, the Visual Analog Scale, the Modified Oswestry Disability Index, and a digital inclinometer were used to assess all patients. Benha University's physical therapy clinics served as the study's sites for outpatient research. Results: The results showed a statistically significant difference between the treatment and control groups (p<0.001), with the treatment group experiencing greater relief from sciatica pain. Conclusion: High intensity laser therapy for four weeks in conjunction with the chosen physical therapy programme was found to be an effective treatment for individuals with sciatica pain, according to the study.