Introduction: Interventional radiology (IR) procedures, known for their minimally invasive approach, have become increasingly prevalent in modern healthcare. However, despite their less invasive nature, these procedures can still result in significant pain for patients. The review aimed to assess the impact of these pain management strategies on patient recovery, satisfaction, and healthcare resource utilization. Methods: The systematic review focused on identifying interventional studies, particularly clinical trials, assessing the effectiveness of potent pain relievers in pain management pre and post Interventional Radiology (IR) procedures. Rigorous search strategies using relevant terms and Boolean operators were applied across comprehensive databases, including PubMed, Embase, Cochrane Library, and Scopus. The emphasis on randomized controlled trials (RCTs) ensured a robust evaluation of intervention efficacy. The systematic study selection process, involving removal of duplicates, title and abstract screening, and full-text assessments, followed stringent eligibility criteria. Results: This systematic review of six interventional studies in Interventional Radiology (IR) procedures reveals significant findings: a multimodal opioid-sparing regimen resulted in a 35% reduction in pain scores (RR 0.65, 95% CI 0.50 -0.85), NSAID regimen showed a 30% reduction in rescue analgesia need (RR 0.70, 95% CI 0.55 -0.90), local anesthesia led to a 40% reduction in pain scores (RR 0.60, 95% CI 0.45-0.80), pre-emptive analgesia protocol resulted in a 35% decrease in pain scores (RR 0.65, 95% CI 0.50-0.85), and combination therapy of opioids and non-opioids yielded a 50% reduction in reported pain levels (RR 0.50, 95% CI 0.35-0.70). Conclusions: These findings highlight a clear trend towards more innovative pain management techniques, emphasizing the need for tailored, patient-centric approaches in IR. This shift not only promises enhanced patient outcomes and quicker recovery times but also aligns with the broader healthcare goal of reducing opioid dependency.