Chromium exposure at a dose of 10 mg/Kg body weight/day for a period of thirty days produced hypoglycaemia and collapses the cerebral metabolic integrity and cellular metabolism in Swiss albino mice. Prognostic changes in feeding behavior, loss of appetite and possible bioaccumulation, stress induced neuronal damage by Cr(VI) in the cerebral tissue may cause the significant weight loss and alteration of CSI. The glycolytic activity was depressed as indicated by less accumulation of pyruvic acid in cerebral tissue. Additionally, chromium significantly inhibit the activities of succinate dehydrogenase and NADH dehydrogenase resulting in impaired oxidation of succinate via TCA cycle and also retardation of energy production through inhibition of mitochondrial respiratory chain. Moreover, the suppressed malate dehydrogenase activity in chromium stressed brain indicates less energy supply to cerebral tissue.