Plant bioactive compounds are being studied for its applications in medicinal field, food industries, cosmetics preparations and other fields. Many plants are exploited for their medicinal property but some plants remain unnoticed. Phoenix pusilla is well-known for its traditional medicinal value however very less scientific proofs are available about this plant. The oral acute toxicity and in vivo antidiabetic and anti-inflammatory activity of the ethanol extract of Phoenix pusilla root and partially purified saponin of Phoenix pusilla were analysed in the present study