Nanoemulsion-based drug delivery systems have emerged as a promising strategy for improving the therapeutic efficacy of various drugs. Nanoemulsions are colloidal dispersions composed of nanoscale droplets of oil or water stabilized by surfactants. Griseofulvin nanoemulsion comprising polymers like medium chain Tri-glycerides, Tween-80 and polyethylene glycol were tested against pathogenic Candida species to determine their antifungal activities. FT-IR, TEM were used to characterise Griseofulvin nanoemulsion, is in range of 10–23 nm. Generally, emulsions are water-in-oil or oil-in water type, but emulsions may contain polar liquid as one of the phase. Emulsions are useful in many situations where presence of water is not desirable, and formulation of active ingredients which undergo hydrolysis or oxidation in the presence of water. The study was to design a stable nanoemulsion (NE) using cosmetically approved ingredients as a vehicle for the watersensitive active ingredients. An optimized NE was obtained through implementation of pseudo-ternary phase diagram. Pseudo-ternary phase diagram was constructed using surfactant and co-surfactant ratio (, 2:1, 3:1,) and nanoemulsion region was determined and further characterized for pH, rheology, globule size analysis, zeta potential and stability.