Male infertility is a growing public health concern. Male infertility can be treated surgically or by interventions, yet both are expensive. Herbal therapies are a popular choice for treating infertility due to the lack of adverse effects and inexpensive. Hemidesmus indicus (HI) is a medicinal plant that is used in traditional medicine to treat infertility by improving the quality of semen , Thus, the current investigation was conducted to assess the reproductive effect of Hemidesmus indicus (HI) extract on Monosodium Glutamate (MSG) triggered alterations in spermiogram and testosterone levels.