In the medicinal world genes play a pivotal role where genomic medicine has set a new shaft in research. Moreover; genetic factors are carrying major position in the progression of periodontal diseases and this inflammation begins as an acute inflammatory response after host-bacterial interaction; proceed into advanced stage which is dominated by B lymphocytes and macrophages, following intense T lymphocytes stage. In the entire process cytokines plays a prevailing role in the transition between these stages. This review narrates the role of cytokines in the inflammation of periodontal disease patterns.