Agriculture is known to be one of the most important sectors worldwide, Agriculture is one of the three most hazardous sectors of activity, both in industrialized and developing countries. In today's society, the agricultural sector employs half of the world's labor force with an estimated 1.3 billion workers active in agricultural production worldwide, Aim: This study aimed to evaluate the effect of agricultural health program for farmer’s regarding health and safety at work place. Research design: A quasi-experimental research design was used in this study. Sample: Purposive sample was used to choose 319 farmers. Setting: The study will conducted in Burqash Village – Imbaba – Giza Governorate. Tool for data collection: One tool as interview questionnaire included five parts, 1st part: demographic characteristic, 2nd part: Past and present history of farmers, 3rd part: Farmers Knowledge about agricultural hazards, 4th part: Farmers reported practice questionnaires and 5th part: Concerned with attitude regarding farmer health and safety pre and post applying program Results: this study showed statistically significant improvement in farmers knowledge ,attitudes and reported practices (6.38±6.00 to 17.84±3.52),( 7.01±1.90 to 17.03±0.662) and (26.30±1.84 to 29.37±3.36) representing pre vs. post program with (P > 0.05). Conclusion: The current study concludes that improvement in farmer’s knowledge, attitudes and reported practices about health and safety at work post agricultural health program than pre also Recommendations: adopting periodic agricultural health program for farmers regarding health and safety with in work place and reorientation sessions about farmer’s health and safety at work, and publication of the program