Physical impairment is a disability that limits a student's physical capacity to move, coordinate actions or performs physical activities. It is accompanied by difficulties in one or more of the following areas: physical and motor tasks, independent movement, and performing daily living functions. Aim: This study aimed to evaluate the effectiveness of the educational program for students with physical impairments at Helwan University. Research design: A quasi-experimental research design was used to conduct this study. Sample: Purposive sample includes 118 students, who suffering from physical impairment. Setting: Excellence center for students with disabilities, three faculties (College of Commerce, college of literature, and the college of law), and emergency clinics at Helwan University. Tool for data collection: One tool, structured interviewer questionnaire, included four parts, 1st part: included socio-demographic characteristic of students with physical impairments, 2nd part: Past and present history of students with physical impairments, 3rd part: Knowledge of students about physical impairments, 4th part: Students reported practice exercises. Results: 80 % of study subjects had a good total knowledge post educational program. 63.6 % of the studied subjects had insufficient reported practice about exercise pre-educational program and improved to 98.3% post educational program. Conclusion: The study concluded that improvement in the student's total knowledge about physical impairments post educational program than pre-educational program. Additionally, there was statistically significant improvement in the student's total reported practice exercises post applying educational program than pre- educational program. Recommendations: Continuous educational program about students with physical impairments in other universities to generalize the results.