The effectiveness of treatment and patient safety in healthcare depend heavily on interactions between patients and professionals as well as adherence to infection control procedures. With an emphasis on the interactions between patients and professionals, this research sought to assess infection control strategies for MRSA-producing bacteria. Methods: The study was conducted to detect nasal carriage of MRSA among ICU staff and non-ICU staff in Synergy Multispecialty Hospital, Vasna Road, Vadodara. Nasal swabs were taken from 30 health care workers who enlisted, 11 of whom worked in the ICU and 19 of whom did not. Results: Staphylococcus aureus was found in 8 of the samples, of which 6 were MSSA and 2 were MRSA. In this investigation, it was observed that S. aureus isolation was more common among ICU staff rather than non ICU staffs. It was also observed that S. aureus strain was common and most virulent among the ICU patients (75%) as compared to non ICU patient (25%). The current finding revealed MRSA, as an irrational danger. Conclusion: MRSA is often spread by either direct or indirect contact with a reservoir. Regularly practice excellent hygiene to lower your chances of contracting MRSA. To reduce the spread of MRSA and infection control failures, more emphasis should be put on individual responsibility for patient-professional interactions.